NOTE: Probiotics are measured by their potency (CFU per gram or number of probiotic cells per gram), not just by how much powder there is. Probiotic powders can be manufactured in different potencies (10 Billion CFU per gram, 100 Billion CFU per gram, 500 Billion CFU per gram, etc). The higher the potency per gram, the less powder you need to take. For example, you would need to take 5 grams of 100 Billion CFU per gram to equal 1 gram of 500 Billion CFU per gram.

L. Rhamnosus 500 billion CFUs/gram (Live Probiotic, No Fillers)

Histamine Free

Ingredients: Lactobacillus Rhamnosus (L. Rhamnosus)

FOR ORAL USE ONLY (taken by mouth).

NOTE: Keep refrigerated upon arrival. 

The probiotics are freeze dried so no ice packs, etc are needed during shipment. 

DO NOT purchase no filler probiotic powder if it is NOT refrigerated. Fillers like maltodextrin, etc keep probiotics stable outside of the refrigerator but cause a lot of digestive problems so we don't use them. The CFU count will be much lower than advertised for no filler powders that are not refrigerated.

We keep all our powders in the refrigerator before shipment.

FREE US SHIPPING. 

*Free international shipping over $100 USD (use code FREESHIPPING at checkout). 

How do I measure this? 

Two measuring spoons are included. The small spoon is 50 Billion CFU (0.1g) and the big spoon is 400 Billion CFU (0.8g). 

Why powder and not capsules?

Our probiotic powder has no additives. Many people don't realize that a lot of additives worsen their symptoms. Additionally, the microbiome in your mouth, esophagus, and stomach are incredibly important to your health. Taking our flavorless probiotic powder keeps those areas healthy. 

Why High Potency? How much should I take? 

Using a dose less than 25 Billion per day will have limited health benefits -- you will need a higher potency to get desirable results. Many people have used other probiotic brands with minimal results because of their low potency. 

It depends on the person and the issue that is being addressed. You’ll start to see results at a minimum of 25 Billion CFUs per day. The average daily dose by our customers is between 200-400 Billion CFUs per day. Some people see significant results with dosages as high as 800 Billion CFUs per day. 

15g Size: 

150 servings if using 50 Billion CFU serving size  (~1/32 teaspoon or 125mg)

50g Size ($1.36 per gram)

5,000 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)

2,500 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)

1,250 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)

500 servings if using 50 Billion CFU serving size (~1/32 teaspoon or 125mg)

200 servings if using 125 Billion CFU serving size (1/16 teaspoon or 0.25g)

100 servings if using 250 Billion CFU serving size (1/8 teaspoon or 0.5g)

50 servings if using 500 Billion CFU serving size (1/4 teaspoon or 1g)

100g Size ($1.03 per gram): 

10,000 servings if using 5 Billion CFU serving size (~1/256 teaspoon or 15.625mg)

5,000 servings if using 10 Billion CFU serving size (~1/128 teaspoon or 31.25mg)

2,500 servings if using 20 Billion CFU serving size (~1/64 teaspoon or 62.5mg)

1,000 servings if using 50 Billion CFU serving size (~1/32 teaspoon or 125mg)

400 servings if using 125 Billion CFU serving size (1/16 teaspoon or 0.25g)

200 servings if using 250 Billion CFU serving size (1/8 teaspoon or 0.5g)

100 servings if using 500 Billion CFU serving size (1/4 teaspoon or 1g)

Statement on Allergens

Dairy Free

Sugar Free

Gluten Free

Preservative Free

Soy Free

GMO Free

Yeast Free

Casein Free

Free of Artificial Colors or Flavors

Prebiotic Free

How long will a 50 gram or 100 gram powder last? 

50 grams will last about 2 months if you take 200 Billion CFUs per day or 8 months if you take 50 Billion CFUs per day. 100 grams will last about 4 months if you take 200 Billion CFUs per day. 

Can infants and children take probiotics? 

Based on existing research, infants can start taking probiotics at 6 months of age. 

How much probiotics can an infant take? 

Infants can take up to 50 Billion CFU per day. 

What are CFUs?

CFU stands for Colony Forming Unit. This is the bacterial count of probiotics. 

Why aren’t BulkProbiotics enteric coated? 

Enteric coated probiotics are mainly a marketing gimmick. The strains that are used at BulkProbiotics are vetted to have excellent acid and bile tolerance as well as the capacity to survive intestinal transit. 

What happens if I leave the probiotics outside of the refrigerator for a couple of days? 

2 year temperature stability testing has been performed on our probiotics and the loss would be negligible. Our probiotics can remain at room temperature (or travel) for 5 weeks with limited loss, however, it is best to store the probiotics in the refrigerator for optimum potency. 

Why do some individuals get a “die-off” reaction? 

This is due to a ‘war’ that occurs between the probiotics and the bad bacteria in your body. If there is a large imbalance in your gut bacteria, the die-off reaction will be higher. To avoid this we recommend that you gradually increase your dosage starting with about 25 Billion CFU per day and increase every few days over a couple of weeks. 

Do your probiotics contain any dairy or gluten? 

Our probiotics are dairy and gluten free. They do not utilize milk, milk derivatives, GOS, or Inulin as additional ingredients in the fermentation media. 

When should I take probiotics? Is it ok to take probiotics with drugs, vitamins, or antibiotics? 

As a digestive aid, it is best to take 30 minutes before a meal; otherwise, it is also ok to take on an empty stomach in the morning or at bedtime (at least 2 hours after eating). Probiotics should not be taken with antibiotics (take 2 hours before or after taking antibiotics). 

What is the return policy?

We accept returns within 30 days for all 10g probiotic powders that are unopened. We do not accept returns for any other sizes. The 10g size is available to experiment to help you find the right probiotic strains for you. 

1. rhamnosus is among the more promising probiotics for skin health, gut health, and respiratory inflammation. It may also help with gestational diabetes and vaginal infections, and new research has introduced the possibility of even more benefits. Read on to learn more about this intriguing probiotic supplement.

What is Lactobacillus rhamnosus?

Lactobacillus rhamnosus is a gram-positive lactic acid bacterium that is part of the normal gut microflora in humans. It is generally regarded as safe and has been used extensively in food products and health supplements.

Among many other health benefits, people take L. rhamnosus to balance their immune system and alleviate allergies and dermatitis.

Mechanisms

In a laboratory setting, researchers have observed that L. rhamnosus:

• Suppressed the production of inflammatory cytokines: IL-4, IL-5, IL-6, IL-8R, IL-13, IL-17, TSLP, IL-1β and TNF-α [1, 2, 3, 4, 5, 6].
• The mechanism of proinflammatory cytokine suppression involves CD4(+) CD25(+) Foxp3(+) Treg cells [1, 7, 3].
• Elevated anti-inflammatory IL-10 [8, 2, 4].
• Elevated and decreases interferon gamma (IFN-γ) [8, 2, 3].
• Elevated IgG and IgA [8, 2].
• Decreased IgE, IgG, IgG1 [2, 9].
• Decreased IGF1 gene expression in the skin [10].
• Increased FOXO1 gene expression in the skin [10].

Potential Benefits of L. rhamnosus

1. rhamnosus probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before using probiotics.

Possibly Effective For

1) Gestational Diabetes

In a study of 373 pregnant women, a probiotic supplement of L. rhamnosus reduced the incidence of gestational diabetes [11].

1. rhamnosus also exerts an anti-diabetic effect in mice, with an anti-hyperglycemic effect in several rodent models. L. rhamnosus further improves glucose tolerance and enhances insulin sensitivity [12].

2) Gut Health

1. rhamnosus has often been selected as candidate probiotic for the prevention and treatment of gastrointestinal infections and diarrhea. It may reduce the duration of diarrhea, particularly in children. It was also shown to reduce the risk of acquiring gastrointestinal infections when administered daily in hospitalized children [13].
2. rhamnosus has been proven to reduce symptoms in children with functional gastrointestinal disorders [14].

It was also beneficial against stress-induced intestinal dysmotility in mice [15].

Diarrhea

Supplementation with L. rhamnosus reduced the incidence of antibiotic-associated diarrhea in patients treated with antibiotics from 22.4% to 12.3% [16].

1. rhamnosus administration was associated with significantly lower rates of and symptomatic rotavirus gastroenteritis diarrhea in hospitalized children L. rhamnosus was well tolerated, and no harms were reported in any of the trials [17].

GI Infections

1. rhamnosus has been shown to prevent enteric colonization by Candida species in preterm neonates and Clostridium difficile induced colitis in children [13].

Ulcers

1. rhamnosus promotes gastric ulcer healing in rats [18].

IBS

1. rhamnosus was beneficial in patients with irritable bowel syndrome [14].

It can reduce pain frequency and intensity in children with abdominal pain-related disorders, particularly among irritable bowel syndrome (IBS) [13].

3) Respiratory Illness

Fermented milk containing L. rhamnosus was efficient in reducing the risk of respiratory tract infections that lasted longer than three days in hospitalized children [13].

Preterm infants treated daily with L. rhamnosus in capsules starting within one week after birth, appear to have a significantly lower incidence of RTIs and rhinovirus-induced episodes in the first 2 months [13].

Consumption of L. rhamnosus reduced the occurrence of respiratory illness in children attending day care centers [19].

Children receiving L. rhamnosus probiotics had fewer days with respiratory symptoms per month than the children in the control group [20].

Capsulated L. rhamnosus was shown to protect hospitalized patients against ventilator-associated pneumonia, mainly when caused by Gram-negative pathogens like Pseudomonas aeruginosa [13].

In cystic fibrosis patients with P. aeruginosa, long-term L. rhamnosus significantly decreased the incidence of pulmonary exacerbations and increased body weight [13].

4) Allergies

Some researchers believe that administration of L. rhamnosus in early life could play a role in food allergy prevention [21].

1. rhamnosus accelerates oral tolerance acquisition in cow’s milk allergic infants [21, 13].

It decreased the allergic response to peanuts in children [22].

1. rhamnosus supplementation shows good clinical and immunologic response in children with allergic rhinitis [7].

The combination of prenatal maternal (2-4 weeks) and postnatal pediatric (6 months) L. rhamnosus treatment in families with a history of atopic disease, significantly lowered the incidence of eczema in children aged 2, 4 and 7 years old [13].

In milk-hypersensitive adults, L. rhamnosus has been shown to reduce the immunoinflammatory response [13].

Consumption of L. rhamnosus-fermented milk by mothers and offspring showed a reduction in physical allergic symptoms in newborn mice [2].

5) Skin Health

Supplementation with L. rhamnosus normalizes skin expression of genes involved in insulin signaling and improves the appearance of adult acne [10].

Eczema

1. rhamnosus efficiently prevents the development of eczema and possibly also atopic sensitization in high-risk infants up to 6 years old [23].

Cumulative prevalence of eczema and prevalence of rhinoconjunctivitis were significantly reduced in the children taking L. rhamnosus [24].

Atopic Dermatitis

1. rhamnosus is effective in decreasing symptoms of atopic dermatitis after 8-weeks of treatment in children aged 4-48 months [25].

Oral application of L. rhamnosus prevents the development of atopic dermatitis in mice by suppressing the production of inflammatory cytokines [1].

6) Vaginal Infections

Probiotic supplementation with vaginal L. rhamnosus is useful in hindering bacteria growth, especially after antibiotic therapy [26].

1. rhamnosus vaginal tablets have demonstrated to be a reliable topical effective and safe treatment to reduce the bacterial vaginosis recurrence rate. No side effects have been reported [27].

7) Weight Management

1. rhamnosus appeared to promote weight loss in women, reducing fat mass and circulating leptin concentrations. However, the weight loss was minor (an additional 1.8 kg compared to the placebo), and the men in the study did not benefit at all. Additional human trials will be required to clarify whether L. rhamnosus can truly promote weight loss [28].
2. rhamnosus significantly lowered weight and demonstrated anti-inflammatory properties in multiple mouse studies [29, 30].

It also protected against high-fat diet-induced adiposity and reversed insulin resistance in mice [31].

It significantly reduced blood levels of triglyceride and cholesterol, decreased liver fat content, and reduced the expressions of lipogenic and pro-inflammatory genes in the livers of mice [32].

8) Liver Function

In obese children with NAFLD, L. rhamnosus restored liver function [33].

1. rhamnosus protects against alcoholic liver injury [34, 5].
2. rhamnosus protects against non-alcoholic fatty liver disease in mice, by increasing beneficial bacteria in the distal small intestine and attenuating liver fat accumulation and portal alanine-aminotransferase concentrations [6].

9) Dental Health

1. rhamnosus reduces oral counts of Streptococcus mutans, a bacterium correlated with the formation of dental caries or cavities [13].

Long-term consumption of L. rhamnosus containing milk reduced the development of cavities in children [13, 35].

10) Immunity

1. rhamnosus activated humoral as well as cellular immune responses in mice [36].

Bacterial Infection

Long-term L. rhamnosus supplementation has an influence on the composition of the intestinal microbiota in children, and reduces the frequency of gastrointestinal complaints after antibiotic use, preventing certain bacterial infections for up to 3 years after the trial [37].

Non-viable L. rhamnosus combats pneumococcal infection in malnourished immunocompromised mice [38].

Mice with pneumonia treated with L. rhamnosus had significantly improved survival [39].

1. rhamnosus can overcome the pathogenic strain Salmonella enterica [40].

Parasitic Infection

1. rhamnosus promotes parasite (nematode) expulsion in mice [41].

Antifungal Activity

1. rhamnosus strains exhibit antimicrobial activity against food spoilage organisms and gastrointestinal pathogens, as well as Candida and Aspergillus [42].

Viral Infection

1. rhamnosus protects against influenza virus infection in mice [43] and beneficially modulates inflammation. Furthermore, the non-viable heat-killed L. rhamnosus is as effective as the viable strain to beneficially modulate respiratory antiviral immune response [44].
2. rhamnosus enhances macrophage viability of herpes (HSV-1) elimination [45].

Treatment of mice with L. rhamnosus significantly reduced lung viral loads and tissue injuries after infection with the respiratory syncytial virus (RSV) [46].

High dose of L. rhamnosus has protective effects against rotavirus infection in newborn mice [47].

11) Pregnancy & Birth

Prenatal supplementation with L. rhamnosus has been reported to change the composition of the newborn microbiota, promoting a beneficial profile dominated by Bifidobacteria [13].

1. rhamnosus affects the immune regulation and immune responses favorably in mothers and offspring. In addition, some of the beneficial effects of prenatal L. rhamnosus supplementation extend into the postnatal life of the offspring, suggesting a possible immune programming effect of L. rhamnosus [8].

It’s important to remember, however, that pregnancy is a sensitive condition, and that each person’s experience is different. If you are pregnant, talk to your doctor before using probiotics.

Animal and Cell Studies (Lacking Evidence)

No clinical evidence supports the use of L. rhamnosus for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

12) Asthma

1. rhamnosus has an anti-inflammatory effect on allergen-induced airway inflammation in mice [9].

Oral administration of L. rhamnosus attenuates the features of allergic asthma in mice [3].

13) Inflammation

1. rhamnosus beneficially regulated the balance between pro- and anti-inflammatory cytokines in the lungs of infant mice [46].
2. rhamnosus ameliorates inflammation by down-regulating pro-inflammatory cytokines in rats [4].

14) Detox

Dietary supplementation with L. rhamnosus reduces absorption and toxicity of consumed organophosphate pesticides in Drosophila [48].

15) Mental Illness

1. rhamnosus administered for 28 days reduced depression in rats [49].
2. rhamnosus decreases anxiety-like behaviors in mice [50].

Both a 2- and 4-week L. rhamnosus pretreatment attenuated OCD-like behavior induction in mice [51].

16) Pain Perception

1. rhamnosus can attenuate neonatally induced chronic visceral pain, and significantly alters levels of serotonin, noradrenaline, and dopamine in rats [52].

Cancer Research

Both viable and nonviable L. rhamnosus kill human cervical and colon cancer cells in a laboratory setting, though these results may not be at all applicable to clinical research [18, 53].

1. rhamnosus has been shown to decrease the incidence of carcinogen-induced colon tumors and precancerous lesions in experimental animals as well as in human cells [53], and possess antitumor effects in animal models of bladder cancer [54].

The effect of L. rhamnosus probiotics on human cancer, if any, is unknown.

Supplementing with L. rhamnosus

Safety

1. rhamnosus is safe and well tolerated in healthy adults, and does not seem to cause adverse effects in young or elderly subjects [55, 56].

However, it should not be taken by immunocompromised individuals where it can lead to bacteremia [57, 58]. Use of probiotics in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms can lead to infections [59].

Food Sources

1. rhamnosus is a human probiotic strain; that is, it is a natural part of the human microbiome. It was first isolated from two healthy adults, Sherwood Gorbach and Barry Goldwin, which is why it got “GG” added to its name [60].

As such, L. rhamnosus is not naturally found in animal- or plant-based foods. Instead, it has to be added during the fermentation process. Various foods may have added L. rhamnosus, including yogurt, cheese, and fermented legumes [61, 62].

*These statements have not been evaluated by the Food and Drug Administration.

*These products are not intended to diagnose, treat, cure, or prevent any disease.