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By Rawan Tarawneh

ISBN: 9783031808487
Published: 02/07/2025
Publisher: Springer Cham
Pages: 637. Hardcover
Number of Illustrations: 
7 b/w illustrations, 32 illustrations in colour

Description: 

Current Progress and Future Directions

• Presents state-of-the-art information on biomarkers for neurodegenerative disorders, a hot topic in neuroscience
• Covers current biomarkers as well as emerging biomarkers and those on the horizon
• Includes coverage of genetic biomarkers for neurodegenerative disorders

This book presents state-of-the-art knowledge regarding fluid and imaging biomarkers of neurodegenerative disorders, including Alzheimer disease and related dementias (ADRD). A cadre of the top experts in the field discuss the diagnostic and prognostic value of established and emerging biomarkers in ADRD, their ability to track or monitor disease progression or predict cognitive outcomes, and their potential as novel therapeutic targets. Biomarkers are discussed both in the context of specific disease mechanisms, including amyloid, tau, and synuclein pathologies, endothelial, vascular, neuronal, and synaptic injury, and glial reactivity as well as a wide spectrum of neurodegenerative disorders that encompass various pathologies. Multi-omics approaches in ADRD biomarker and drug target discovery including proteomics, genomics, and transcriptomics are covered. Importantly, the authors highlight the need to integrate biomarkers into various stages of ADRD drug development to accelerate drug discovery and approval. The book provides in-depth insight regarding significant progress in ADRD biomarker research over the last decade, addresses potential challenges in the translation of ADRD biomarkers into the clinic, and proposes important directions for future research.

Table of Contents:

Fluid and Imaging Markers of Amyloid Pathology
Tim West, Matthew R. Meyer, Kristopher M. Kirmess, Kevin E. Yarasheski, Joel B. Braunstein, Philip B. Verghese

Fluid Markers of Tau Pathology
Naazneen Khan, Jeffrey L. Dage

Fluid and Imaging Markers of Synuclein Pathology
Federico Paolini Paoletti, Lorenzo Gaetani, Giovanni Bellomo, Lucilla Parnetti

Fluid and Imaging Markers of Synaptic Injury
Rawan Tarawneh

Fluid Markers of Axonal and Neuronal Injury
Burak Arslan, Henrik Zetterberg

Fluid and Imaging Markers of Glial Reactivity
Marc Suárez-Calvet

Fluid and Imaging Markers of Vascular Disease
Gary A. Rosenberg

Fluid Markers of Alzheimer Disease
Courtney L. Sutphen, Katherine Volluz, Rawan Tarawneh

Fluid and Imaging Markers of Frontotemporal Lobar Degeneration
Fieke A. M. Prinse, Julie F. H. De Houwer, Elise G. P. Dopper, Harro Seelaar

Fluid and Imaging Markers of Lewy Body Dementias
Kayla Julio, Harm Jan van der Horn, Sephira G. Ryman

Fluid and Imaging Markers of Huntington’s Disease
Mena Farag, Rachael I. Scahill, Edward J. Wild, Sarah J. Tabrizi

Proteomics for Novel Biomarker and Drug Target Discovery in Alzheimer Disease
Huiming Zhu, Minqi Cai, Dezhu Chen, Jiaojiao Sha, Liangjia Du, Yiqiang Chen et al.

Genomics and Transcriptomics of Alzheimer Disease
Natalia Vilor-Tejedor, Blanca Rodriguez-Fernandez, Patricia Genius, Emma S. Luckett, Federica Anastasi, Luigi Lorenzini et al.

Biomarkers in Clinical Trials of Alzheimer Disease: An Overview
Fabricio Ferreira de Oliveira, Raphael Machado Castilhos, Artur Martins Coutinho, Alan Cronemberger Andrade, Yun Jin Kim, Fardin Nabizadeh et al.

Biomarkers as Outcome Measures in Clinical Trials of Alzheimer Disease
Rawan Tarawneh

Impact of Pre-analytical Factors on Fluid Biomarker Measurements in Alzheimer Disease
Javier Torres-Torronteras, Mariam Gouda, Charlotte E. Teunissen, Inge M. W. Verberk, Marta del Campo

Mild Behavioral Impairment and Alzheimer Disease Biomarkers: Sample Enrichment for Clinical Trial Screening and Recruitment
Maryam Ghahremani, Rebeca Leon, Daniella Vellone, Dylan Guan, Zahra Hosseinpour, Jasper Crockford et al.

Extracellular Vesicles as Biomarkers of Alzheimer Disease and Related Dementias
Zainab Mianoor, Jolene Phelps, AmanPreet Badhwar

Sex Differences in Alzheimer Disease-Related Biomarkers and Dementia Risk
Sima Toopchiani, Anne Nyambura Njogu, Cynthia Smith, Shireen Sindi, Onah Okoye, Tamlyn Watermeyer et al.

Imaging Markers of Amyloid and Tau in Alzheimer Disease
Rawan Tarawneh

Fluid Markers of Brain Endothelial Injury
Rawan Tarawneh

Keywords: 
biomarkers, neurodegenerative disorders, parkinson's disease, dementia, alzheimer's, neuropharmacology, frontotemporal dementia, Lewy body dementia

Target Audience: neurologists, neuroscientists, clinical researchers, graduate students, pharmaceutical professionals.

Genre: medical science, neuroscience, academic reference, clinical research, biotechnology

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