LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.

Product information

CAS Number: 2173232-79-4

Molecular Weight: 258.30

Formula: C13H10N2O2S

Chemical Name: 3-(dimethylamino)-4H,9H-naphtho[2,3-d][1,2]thiazole-4,9-dione

Smiles: CN(C)C1=NSC2=C1C(=O)C1=CC=CC=C1C2=O

InChiKey: LMNFZYAIQJKFFX-UHFFFAOYSA-N

InChi: InChI=1S/C13H10N2O2S/c1-15(2)13-9-10(16)7-5-3-4-6-8(7)11(17)12(9)18-14-13/h3-6H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 6 mg/mL (23.23 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).

Products are for research use only. Not for human use.