NEDD8 Activating Enzyme E1C Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB12290-50, MB12290-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q8TBC4

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB,

All Applications: WB: 1/500-1/1000

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 52 kDa; Observed MW: 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of UBA3 in Raw264.7 lysates using NEDD8 Activating Enzyme E1C antibody., Western blot analysis of UBA3 in Hela, A549, HL-60 lysates using UBA3 antibody.

Alternative Name: NAE2; UBE1C; hUBA3

Immunogen: A synthetic peptide of human UBA3

Conjugate: Unconjugated

Modification: Unmodified