Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.

Product information

CAS Number: 203120-17-6

Molecular Weight: 346.34

Formula: C13H22N4O7

Chemical Name: (2R,3R,4S)-4-[(diaminomethylidene)amino]-2-[(1R,2R)-2,3-dihydroxy-1-methoxypropyl]-3-acetamido-3,4-dihydro-2H-pyran-6-carboxylic acid

Smiles: CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@H](OC)[C@H](O)CO)C(O)=O)N=C(N)N

InChiKey: QNRRHYPPQFELSF-CNYIRLTGSA-N

InChi: InChI=1S/C13H22N4O7/c1-5(19)16-9-6(17-13(14)15)3-8(12(21)22)24-11(9)10(23-2)7(20)4-18/h3,6-7,9-11,18,20H,4H2,1-2H3,(H,16,19)(H,21,22)(H4,14,15,17)/t6-,7+,9+,10+,11+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 5 mg/mL (14.44 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution. Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir.

Products are for research use only. Not for human use.