N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2183440-70-0

Molecular Weight: 581.66

Formula: C24H47N5O11

Chemical Name: 3-{2-[2-(2-{3-[2-(2-aminoethoxy)ethoxy]-N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)propanamido}ethoxy)ethoxy]ethoxy}propanoic acid

Smiles: [N-]=[N+]=NCCOCCOCCOCCN(CCOCCOCCOCCC(O)=O)C(=O)CCOCCOCCN

InChiKey: FZLMDRGRFLPQRO-UHFFFAOYSA-N

InChi: InChI=1S/C24H47N5O11/c25-3-9-35-15-13-33-7-1-23(30)29(5-11-37-17-21-39-19-14-34-8-2-24(31)32)6-12-38-18-22-40-20-16-36-10-4-27-28-26/h1-22,25H2,(H,31,32)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.