CD10 Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA22903-50, RA22903-100 Citations, Manuals and MSDS Available upon request. Background: membrane metalloendopeptidase (MME) Homo sapiens This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL) . This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IHC 1:100-200 Alternative Names: MME Applications: IHC-p; IF (paraffin section) Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 4311 Protein MW (KDa): 85 SWISS: P08473 Source: Rabbit Research Use Only