DS16570511 is cell-permeable inhibitor of the mitochondrial calcium uniporter, which blocks the MCU- or MICU1-dependent increase of Ca2+ influx.

Product information

CAS Number: 2446154-84-1

Molecular Weight: 562.44

Formula: C30H25Cl2N3O4

Chemical Name: 4-{3-[3-({[3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]methyl}amino)benzoyl]-1H-indol-1-yl}butanoic acid

Smiles: CC1ON=C(C2=C(Cl)C=CC=C2Cl)C=1CNC1C=C(C=CC=1)C(=O)C1=CN(CCCC(O)=O)C2C=CC=CC=21

InChiKey: VIWYGRDFHWYDRW-UHFFFAOYSA-N

InChi: InChI=1S/C30H25Cl2N3O4/c1-18-22(29(34-39-18)28-24(31)10-5-11-25(28)32)16-33-20-8-4-7-19(15-20)30(38)23-17-35(14-6-13-27(36)37)26-12-3-2-9-21(23)26/h2-5,7-12,15,17,33H,6,13-14,16H2,1H3,(H,36,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (222.25 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DS16570511 dose-dependently inhibits serum-induced mitochondrial Ca2+ influx in HEK293A cells with an IC50 of 7 μM. DS16570511 inhibits Ca2+ uptake of isolated mitochondria from human cells, rat heart and pig heart.

Products are for research use only. Not for human use.