Recombinant Human LMCD1/Dyxin Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032706-10, PKSH032706-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: LMCD1; Dyxin

Target Synonym: LIM and cysteine-rich domains protein 1; LMCD1; Dyxin

UNIProt ID: Q9NZU5

Research Areas: Signal Transduction; Neuroscience;

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His & C-His

Accession: Q9NZU5

Background: LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Sequence: Met 1-Ser365

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 44.0 kDa

Observed MW: 45 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only