EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

Product information

CAS Number: 2225887-26-1

Molecular Weight: 571.69

Formula: C31H38FN9O

Chemical Name: {1-[6-({5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl}amino)-2-[(4-fluorophenyl)amino]pyrido[3, 4-d]pyrimidin-4-yl]piperidin-4-yl}methanol

Smiles: CN(C)C1CCN(CC1)C1=CN=C(C=C1)NC1=CC2=C(N=C(NC3=CC=C(F)C=C3)N=C2C=N1)N1CCC(CO)CC1

InChiKey: DXOUQSZKEPSXBC-UHFFFAOYSA-N

InChi: InChI=1S/C31H38FN9O/c1-39(2)24-11-15-40(16-12-24)25-7-8-28(33-18-25)37-29-17-26-27(19-34-29)36-31(35-23-5-3-22(32)4-6-23)38-30(26)41-13-9-21(20-42)10-14-41/h3-8,17-19,21,24,42H,9-16,20H2,1-2H3,(H,33,34,37)(H,35,36,38)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237.

Products are for research use only. Not for human use.