APC (phospho Ser2054) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21958-50, RA21958-100

Citations, Manuals and MSDS Available upon request.

Background: APC, WNT signaling pathway regulator (APC) Homo sapiens This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Alternative Names: APC; DP2.5; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 324

Protein MW (KDa): 311

SWISS: P25054

Source: Rabbit

Research Use Only