PTBP1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91130-50, BS91130-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P26599(Human) P17225(Mouse) Q00438(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500-2,000
IHC:1:50-1:200

Background: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: PTBP1 polyclonal antibody detects endogenous levels of PTBP1 protein.

Bioworld Molecular Weight: 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of PTBP1 on different lysates using anti-PTBP1 antibody at 1/500 dilution.
Positive control:
Lane 1: K562
Lane 2: Jurkat
Lane 3: Mouse colon tissue, Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PTBP1 antibody. Counter stained with hematoxylin.

Alternative Name: PTB, hnRNP I, PTBP1, 57 kDa RNA binding protein PPTB 1, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, hnRNP I, HNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), Polypyrimidine Tract Binding Protein 1, Polypyrimidine tract binding protein, Polypyrimidine tract-binding protein 1, pPTB, PTB 1, PTB 2, PTB 3, PTB 4, PTB, PTB T, PTB1, PTB2, PTB3, PTB4, PTBP 1, PTBP1, PTBP1, PTBT, RNA Binding Protein,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified